Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

Abstract

Direct reprogramming of adult somatic cells into alternative cell types has been shown for several lineages. We previously showed that GATA4, MEF2C, and TBX5 (GMT) directly reprogrammed nonmyocyte mouse heart cells into induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. However, GMT alone appears insufficient in human fibroblasts, at least in… (More)
DOI: 10.1016/j.stemcr.2013.07.005

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