Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY

  title={Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY},
  author={Phoebe Dewing and Charleston W. K. Chiang and Kevin Sinchak and Helena Sim and Pierre-Olivier Fernagut and Sabine Kelly and M. -F. Chesselet and Paul E Micevych and Kenneth H. Albrecht and Vincent R Harley and Eric Vilain},
  journal={Current Biology},

Figures and Tables from this paper

Sex differences in brain developing in the presence or absence of gonads
Differences in the area and distribution of immunoreactive calbindin and neuronal nitric oxide synthase in the preoptic area and ventromedial nucleus of the hypothalamus were maintained in male and female SF‐1 KO mice, suggesting gonad‐independent genetic influences on sexually dimorphic brain development.
Sexual differentiation of the brain: investigating the role of Sry using animal models
This thesis investigated the roles of the Y-linked (male-specific) gene Sry and other sex chromosome-linked genes on emotional behaviour in rodent models and attempted to dissociate ‘Sry-dependent effects’ and effects due to ‘sex chromosome complement’.
Morphological analyses of sex differences and age-related changes in C3H mouse midbrain.
The female ventral tegmental area of C3H mice appeared to contain higher immunoreactivity to tyrosine hydroxylase (TH) than that of males at 11 weeks of age, whereas general histological differences between the sexes were not clearly found.
Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids.
It is shown that testosterone and its metabolite dihydrotestosterone are essential for hippocampal synaptic transmission specifically in males, and these findings argue for sex-dependent differentiation of hippocampal neurons regarding their responsiveness to sex neurosteroids up to birth, which persist during adulthood.
The control of sexual differentiation of the reproductive system and brain.
This review summarizes current knowledge of the genetic and hormonal control of sexual differentiation of the reproductive system, brain and brain function and the effects of endocrine disruptors on sexual differentiation is presented.
X chromosome number causes sex differences in gene expression in adult mouse striatum
Quantitative PCR confirmed that GDX XX mice have higher Pdyn expression in striatum than XY mice, regardless of their gonadal sex, indicating that the sex chromosome effect is the result of XX vs. XY differences in the number of X chromosomes.
Inhibition of SRY-calmodulin complex formation induces ectopic expression of ovarian cell markers in developing XY gonads.
It is shown that mouse Sry protein binds CaM and that a CaM antagonist reduces CaM binding, nuclear accumulation, and transcriptional activity of Sry in transfected cells, indicating the importance of CaM for SRY nuclear import, transcriptionalActivity, testis differentiation, and sex determination.


The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain
It is proposed that neurons are capable of acquiring sex-specific properties independently of their hormonal environment, and two Y-chromosomal genes involved in sex determination of the gonad are transcribed in hypothalamus, and frontal and temporal cortex of the adult male human brain.
Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation.
Are XX and XY brain cells intrinsically different?
Developmental profile of Sry transcripts in mouse brain
The change from one transcript form to the other suggests that expression of the Sry gene in mouse brain is developmentally regulated, presumably by a switch in promoter selection, which supports the notion that Sry expression in brain is biologically significant.
Sexual differentiation of the vertebrate nervous system
Some of the events triggered by testosterone that masculinize the developing and adult nervous system, promote male behaviors and suppress female behaviors are reviewed.
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Observations show the essential role of estrogen in maintaining the integrity of the nigral dopamine system, suggest a new treatment strategy for patients with Parkinson's disease and with certain forms of memory-impairing disorders, and provide another rationale for estrogen replacement therapy for postmenopausal women.
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.
It is demonstrated that Nurr1 functions at the later stages of dopamine cell development to drive differentiation of ventral mesencephalic late dopaminergic precursor neurons, and is essential for specifying commitment of mesENCEphalic precursors to the full dopamine phenotype.
Regulation of tyrosine hydroxylase gene transcription by Sry
Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.
The hypothesis that Sry initiates testis differentiation by directing the development of supporting cell precursors as Sertoli rather than granulosa cells is supported and the Sry expression pattern explains the nonrandom distribution of testicular and ovarian tissue in mammalian ovotestes.