Direct Oral Anticoagulant Agents: Pharmacologic Profile, Indications, Coagulation Monitoring, and Reversal Agents.

@article{Rose2018DirectOA,
  title={Direct Oral Anticoagulant Agents: Pharmacologic Profile, Indications, Coagulation Monitoring, and Reversal Agents.},
  author={Deborah K Rose and Barak Bar},
  journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year={2018},
  volume={27 8},
  pages={
          2049-2058
        }
}
  • Deborah K Rose, Barak Bar
  • Published in
    Journal of stroke and…
    2018
  • Medicine
  • Vitamin K antagonists (VKAs), such as warfarin, have been used for thromboprophylaxis and for the treatment of thromboembolic events in patients with nonvalvular atrial fibrillation for over 60 years. The increasing use of direct oral anticoagulants (DOACs) in recent years has shown greater advantages and safer use over VKA, including reduced bleeding, fewer drug interactions, no food interactions, a quick onset and offset of activity, and predictable dose-response properties. Despite their… CONTINUE READING

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