Direct, Mild, and General n-Bu4NBr-Catalyzed Aldehyde Allylsilylation with Allyl Chlorides.

Abstract

A direct, mild, and general method for the enantioselective allylsilylation of aldehydes with allyl chlorides is reported. The reactions are effectively catalyzed by 5 mol % of n-Bu4NBr, and this rate acceleration allows the use of complex allyl donors in fragment-coupling reactions and of electron-deficient allyl donors. The results are (1) significant… (More)
DOI: 10.1021/acs.orglett.7b03193

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Cite this paper

@article{TekleSmith2017DirectMA, title={Direct, Mild, and General n-Bu4NBr-Catalyzed Aldehyde Allylsilylation with Allyl Chlorides.}, author={Makeda A Tekle-Smith and Kevin S Williamson and Isaac F Hughes and James L Leighton}, journal={Organic letters}, year={2017}, volume={19 21}, pages={6024-6027} }