Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins.

@article{Jin2017DirectLC,
  title={Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins.},
  author={Xiaoying Jin and L. Liu and S. Nass and C. O’Riordan and E. Pastor and X. Zhang},
  journal={Human gene therapy methods},
  year={2017},
  volume={28 5},
  pages={
          255-267
        }
}
The requirement for robust analytical methods to characterize adeno-associated virus (AAV) vectors is immediate, as the field advances more AAV gene therapies into the clinic and onto commercialization. AAV capsid proteins (VPs) are critical for viral infectivity and vector potency. Thus, complete characterization of the constituent viral capsid proteins of AAV vectors, including their sequences and post-translational modifications (PTMs), is highly recommended to ensure AAV product quality and… Expand
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