Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

@inproceedings{Cassady2014DirectLC,
  title={Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells},
  author={John P. Cassady and Ana C. D’Alessio and Sovan Sarkar and Vardhan S. Dani and Z. P. Fan and Kibibi Ganz and Reinhard Roessler and Mriganka Sur and Richard A. Young and Rudolf Jaenisch},
  booktitle={Stem cell reports},
  year={2014}
}
Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons and glia. However, the ability to maintain the NSC state independent of the inducing factors and the identity of the somatic donor cells remain two important unresolved issues in transdifferentiation. Here we used transduction of doxycycline-inducible transcription factors… CONTINUE READING