Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization

@article{Purohit1999DirectIO,
  title={Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization},
  author={Aruna Purohit and Sharon H. Tynan and Richard B Vallee and Stephen John Doxsey},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={147},
  pages={481 - 492}
}
Pericentrin is a conserved protein of the centrosome involved in microtubule organization. To better understand pericentrin function, we overexpressed the protein in somatic cells and assayed for changes in the composition and function of mitotic spindles and spindle poles. Spindles in pericentrin-overexpressing cells were disorganized and mispositioned, and chromosomes were misaligned and missegregated during cell division, giving rise to aneuploid cells. We unexpectedly found that levels of… CONTINUE READING

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Colocalization of dynactin and cytoplasmic dynein with CLIP-170 at microtubule distal ends

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