Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster

@article{HaagLiautard2008DirectEO,
  title={Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster},
  author={Cathy Haag-Liautard and Nicole Coffey and David Houle and Michael Lynch and Brian Charlesworth and Peter D. Keightley},
  journal={PLoS Biology},
  year={2008},
  volume={6},
  pages={729 - 744}
}
Mitochondrial DNA (mtDNA) variants are widely used in evolutionary genetics as markers for population history and to estimate divergence times among taxa. Inferences of species history are generally based on phylogenetic comparisons, which assume that molecular evolution is clock-like. Between-species comparisons have also been used to estimate the mutation rate, using sites that are thought to evolve neutrally. We directly estimated the mtDNA mutation rate by scanning the mitochondrial genome… CONTINUE READING

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