Direct Detection of Pixel-Level Myocardial Infarction Areas via a Deep-Learning Algorithm


Accurate detection of the myocardial infarction (MI) area is crucial for early diagnosis planning and follow-up management. In this study, we propose an end-to-end deep-learning algorithm framework (OF-RNN ) to accurately detect the MI area at the pixel level. Our OFRNN consists of three different function layers: the heart localization layers, which can accurately and automatically crop the region-of-interest (ROI) sequences, including the left ventricle, using the whole cardiac magnetic resonance image sequences; the motion statistical layers, which are used to build a time-series architecture to capture two types of motion features (at the pixel-level) by integrating the local motion features generated by long short-term memory-recurrent neural networks and the global motion features generated by deep optical flows from the whole ROI sequence, which can effectively characterize myocardial physiologic function; and the fully connected discriminate layers, which use stacked auto-encoders to further learn these features, and they use a softmax classifier to build the correspondences from the motion features to the tissue identities (infarction or not) for each pixel. Through the seamless connection of each layer, our OF-RNN can obtain the area, position, and shape of the MI for each patient. Our proposed framework yielded an overall classification accuracy of 94.35% at the pixel level, from 114 clinical subjects. These results indicate the potential of our proposed method in aiding standardized MI assessments.

DOI: 10.1007/978-3-319-66179-7_28

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@inproceedings{Xu2017DirectDO, title={Direct Detection of Pixel-Level Myocardial Infarction Areas via a Deep-Learning Algorithm}, author={Chenchu Xu and Lei Xu and Zhifan Gao and Shen Zhao and Heye Zhang and Yanping Zhang and Xiuquan Du and Shu Zhao and Dhanjoo N. Ghista and Shuo Li}, booktitle={MICCAI}, year={2017} }