Direct Catalytic Asymmetric Synthesis of β-Hydroxy Acids from Malonic Acid.

Abstract

A nickel(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.

DOI: 10.1021/acs.orglett.5b02891

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Cite this paper

@article{Gao2015DirectCA, title={Direct Catalytic Asymmetric Synthesis of β-Hydroxy Acids from Malonic Acid.}, author={Hang Gao and Zhenli Luo and Pingjin Ge and Junqian He and Feng Zhou and Peipei Zheng and Jun Jiang}, journal={Organic letters}, year={2015}, volume={17 24}, pages={5962-5} }