Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo.


CD1d-restricted NKT cells rapidly stimulate innate and adaptive immunity through production of Th1 and/or Th2 cytokines and induction of CD1d(+) APC maturation. However, therapeutic exploitation of NKT cells has been hampered by their paucity and defects in human disease. NKT cell-APC interactions can be modeled by direct stimulation of human APCs through… (More)
DOI: 10.4049/jimmunol.0800924


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