• Corpus ID: 101129241

Direct Base-to-Base Transitions in ssDNA Revealed by Tip-Enhanced Raman Scattering

  title={Direct Base-to-Base Transitions in ssDNA Revealed by Tip-Enhanced Raman Scattering},
  author={Xiumei Lin and Tanja Deckert-Gaudig and Prabha Singh and Michel Siegmann and Stephan Kupfer and Zhenglong Zhang and Stefanie Grafe and Volker Deckert},
  journal={arXiv: Chemical Physics},
In the present contribution, specifically designed single-stranded DNA (ssDNA) sequences composed of adenine and cytosine were used as nanometric rulers to target the maximum achievable spatial resolution of tip-enhanced Raman spectroscopy (TERS) under ambient conditions. By stepping along a strand with a TERS tip, the obtained spectra allowed for a clear spectral discrimination including conformational information of the nucleobases, and even sharp adenine-cytosine transitions were detected… 

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