Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

@inproceedings{Oikawa2012DirectAO,
  title={Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β},
  author={Daisuke Oikawa and Akira Kitamura and Masataka Kinjo and Takao Iwawaki},
  booktitle={PloS one},
  year={2012}
}
IRE1, an ER-localized transmembrane protein, plays a central role in the unfolded protein response (UPR). IRE1 senses the accumulation of unfolded proteins in its luminal domain and transmits a signal to the cytosolic side through its kinase and RNase domains. Although the downstream pathways mediated by two mammalian IRE1s, IRE1α and IRE1β, are well documented, their luminal events have not been fully elucidated. In particular, there have been no reports on how IRE1β senses the unfolded… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Signal integration in the endoplasmic reticulum unfolded protein response

Nature Reviews Molecular Cell Biology • 2007
View 6 Excerpts
Highly Influenced

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 4 Excerpts
Highly Influenced

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