Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

  title={Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β},
  author={Daisuke Oikawa and Akira Kitamura and Masataka Kinjo and Takao Iwawaki},
  booktitle={PloS one},
IRE1, an ER-localized transmembrane protein, plays a central role in the unfolded protein response (UPR). IRE1 senses the accumulation of unfolded proteins in its luminal domain and transmits a signal to the cytosolic side through its kinase and RNase domains. Although the downstream pathways mediated by two mammalian IRE1s, IRE1α and IRE1β, are well documented, their luminal events have not been fully elucidated. In particular, there have been no reports on how IRE1β senses the unfolded… CONTINUE READING


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