Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes

@article{Onali2010DirectAA,
  title={Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes},
  author={P. Onali and S. Dedoni and M. Olianas},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={332},
  pages={255 - 265}
}
Tricyclic antidepressants (TCAs) have been reported to interact with the opioid system, but their pharmacological activity at opioid receptors has not yet been elucidated. In the present study, we investigated the actions of amoxapine, amitriptyline, nortriptyline, desipramine, and imipramine at distinct cloned and native opioid receptors. In Chinese hamster ovary (CHO) cells expressing δ-opioid receptors (CHO/DOR), TCAs displaced [3H]naltrindole binding and stimulated guanosine 5′-O-(3-[35S… Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors
TLDR
It is demonstrated that NalBzoH displays agonist activity at MOR, DOR and KOR expressed either in a heterologous cell system or in a native environment, and showed an efficacy that was lower than that of morphine at MOR but higher at KOR and DOR. Expand
Tricyclic antidepressants inhibit opioid receptor binding in human brain and hepatic morphine glucuronidation.
TLDR
The opioid receptor binding in the human thalamic area was studied with U-69593 and naloxone as ligands for the kappa and mu receptors, respectively and inhibition was observed at a tricyclic antidepressant/morphine concentration ratio close to that achieved in plasma from patients treated with these drugs. Expand
Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds.
TLDR
The relative potency of the tricyclic antidepressants with regard to inhibitions of opiate binding in brain did not correlate with their clinical efficiency as antidepressants, suggesting that these compounds probably do not exert their antidepressant effects through opioid peptidergic systems in brain. Expand
Effects of antidepressant drugs on different receptors in the brain.
TLDR
Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors and found that all the antidepressants tested were practically devoid of activity on DHA binding, Spiroperidol binding, [3H]flunitrazepam binding, and Naloxone binding. Expand
Mixed Agonist–Antagonist Properties of Clozapine at Different Human Cloned Muscarinic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells
TLDR
The data indicate that clozapine behaves as a partial agonist at different muscarinic receptor subtypes and may provide new hints for understanding the receptor mechanisms underlying the antipsychotic efficacy of the drug. Expand
Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline
TLDR
Changes induced by antidepressants in opioidergic markers at the spinal level might account for the potentiation of the action of morphine in amoxapine- or amitriptyline-treated rats, and the observed alterations in the same markers in the hypothalamus could be associated with changes induced by antidepressant in neuroendocrine regulation. Expand
Chronic Antidepressant Treatment Causes a Selective Reduction of μ-Opioid Receptor Binding and Functional Coupling to G Proteins in the Amygdala of Fawn-Hooded Rats
  • F. Chen, A. Lawrence
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2004
TLDR
The present findings suggest that antidepressants regulate opioid systems; however, and region-specific alteration of functional coupling of μ-opioid receptors to G proteins in the amygdala suggests that opioid function within the amygdala may be modulated by antidepressants. Expand
The antidepressant -like effects of delta-opioid receptor agonists.
TLDR
The role of the DORs in depression and the antidepressant-like effects of delta-opioid agonists as well as their limitations are discussed. Expand
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds
TLDR
The mechanism of antidepressant‐induced antinociception is different from that of the non‐steroidal anti‐inflammatory drugs and is consistent with the view that antidepressants may induce endogenous opioid peptide release, as shown by the acetorphan study. Expand
Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications
TLDR
The present review tries to unravel controversial findings and provides a hypothesis that may help to integrate diverse results that are still unclear whether these properties are mediated through typical opioid receptor activation and inhibitory G-protein-signaling. Expand
...
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4
5
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