Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes

  title={Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes},
  author={Pierluigi Onali and Simona Dedoni and Maria C. Olianas},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={255 - 265}
Tricyclic antidepressants (TCAs) have been reported to interact with the opioid system, but their pharmacological activity at opioid receptors has not yet been elucidated. In the present study, we investigated the actions of amoxapine, amitriptyline, nortriptyline, desipramine, and imipramine at distinct cloned and native opioid receptors. In Chinese hamster ovary (CHO) cells expressing δ-opioid receptors (CHO/DOR), TCAs displaced [3H]naltrindole binding and stimulated guanosine 5′-O-(3-[35S… 

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