Direct Activation of Sleep-Promoting VLPO Neurons by Volatile Anesthetics Contributes to Anesthetic Hypnosis

@article{Moore2012DirectAO,
  title={Direct Activation of Sleep-Promoting VLPO Neurons by Volatile Anesthetics Contributes to Anesthetic Hypnosis},
  author={Jason T. Moore and Jingqiu Chen and Bo Han and Qing Cheng Meng and Sigrid Carlen Veasey and Sheryl G. Beck and Max B Kelz},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={2008-2016}
}
BACKGROUND Despite seventeen decades of continuous clinical use, the neuronal mechanisms through which volatile anesthetics act to produce unconsciousness remain obscure. One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous arousal circuits. A key sleep-promoting component of this circuitry is the ventrolateral preoptic nucleus (VLPO), a hypothalamic region containing both state-independent neurons and neurons that preferentially fire during natural… CONTINUE READING
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