Direct Activation of Human CD8+ Cytotoxic T Lymphocytes by Interleukin‐18

@inproceedings{Kohyama1998DirectAO,
  title={Direct Activation of Human CD8+ Cytotoxic T Lymphocytes by Interleukin‐18},
  author={Masako Kohyama and Kaoru Saijyo and Midori Hayasida and Tomoko Yasugi and Masashi Kurimoto and Tadao Ohno},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
Direct activation of human cytotoxic T lymphocytes (CTL) by interleukin (IL)-18 was observed in a system in which CTL effective against autologous tumor cells were generated. Peripheral blood mononuclear cells (PBMC) from tumor-bearing patients, after removal of natural killer (NK) cells, were cultured in a medium containing IL-1, -2, -4, and -6, with or without IL-18, and stimulated with autologous tumor cells. IL-18 increased the activity of the CTL and the proportion of autologous CD8+ T… CONTINUE READING
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