Direct AAV-mediated gene delivery to the temporomandibular joint.

  title={Direct AAV-mediated gene delivery to the temporomandibular joint.},
  author={Juan Dai and Abou Bakr Mahmoud Rabie},
  journal={Frontiers in bioscience : a journal and virtual library},
Successful intra-temporomandibular joint gene transfer is a prerequisite for gene therapy to induce mandibular condylar growth. This study was carried out to investigate the expression of recombinant adeno-associated virus (rAAV) based vector-mediated enhanced green fluorescence protein (eGFP) in the mandibular condyle. The transduction efficiencies for primary chondrocytes using different hybrids of rAAV vectors were identified by fluorescence microscopy and FACS. Sprague-Dawley rats were… CONTINUE READING