Direct 99mTc labeling of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and non-invasive imaging studies.

@article{Bao2004Direct9L,
  title={Direct 99mTc labeling of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and non-invasive imaging studies.},
  author={A Ru Han Bao and Beth Ann Goins and Robert Klipper and George R. Negrete and William Thomas Phillips},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 2},
  pages={419-25}
}
Pharmacokinetic and organ distribution studies of liposomal drugs in humans are a challenge. A direct labeling method using (99m)Tc-N,N-bis(2-mercaptoethyl)-N',N'-diethyl-ethylenediamine (BMEDA) complex to label the commercially available pegylated liposomal doxorubicin, Doxil, has been introduced. Biodistributions of (99m)Tc-Doxil in normal rats were performed to evaluate the feasibility of using it for monitoring the pharmacokinetics of liposomes encapsulating drugs. Labeling efficiency of… CONTINUE READING
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