Direct, simultaneous measurement of chloramphenicol and its monosuccinate ester in micro-samples of plasma by radial-compression liquid chromatography.

A simple method of simultaneous analysis for chloramphenicol and chloramphenicol succinate in 10-microL samples of plasma is described. We injected the plasma samples directly into a radial-compression liquid chromatograph equipped with a precolumn module and a C18 insert. A mixture of acetic acid solution (pH 3)/acetonitrile (75/25, by vol) was used as… (More)