Direct, noncatalytic mechanism of IKK inhibition by A20.

  title={Direct, noncatalytic mechanism of IKK inhibition by A20.},
  author={Brian A Skaug and Jueqi Chen and Fenghe Du and Jin He and Averil Ma and Zhijian J Chen},
  journal={Molecular cell},
  volume={44 4},
A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ multiple mechanisms to antagonize ubiquitination upstream of NEMO, a regulatory subunit of the IκB kinase complex (IKK). However, direct evidence of IKK inhibition by A20 is lacking, and the inhibitory mechanism remains poorly understood. Here we show that A20 can directly impair IKK activation without… CONTINUE READING


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