Direct, microwave-assisted substitution of anomeric nitrate-esters.

Abstract

A series of carbohydrate 2-azido-1-nitrate-esters, protected at the C-3, C-4, and C-6 positions, were hydrolyzed thermally under reagent free conditions. This preliminary result was extended to direct exchange of the 1-nitrate-ester modality for alcohol, alkoxy, and azide coupling partners with minimal purification. While direct glycosylation of nitrate… (More)
DOI: 10.1016/j.carres.2017.02.005

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