Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.

@article{Hinz2007DipyroneES,
  title={Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.},
  author={Burkhard Hinz and Olga Cheremina and Jouri Bachmakov and Bertold Renner and Oliver Zolk and Martin F. Fromm and Kay Brune},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 10},
  pages={2343-51}
}
Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread prescription or over-the-counter use in many countries (e.g., Brazil, Israel, Mexico, Russia, Spain) requires insight into its mode of action. This study therefore addressed the impact of its metabolites 4-methyl-amino-antipyrine (MAA) and 4-amino-antipyrine (AA) on peripheral cyclooxygenases (COX). Pharmacokinetics of metabolites and ex vivo COX inhibition were assessed in five volunteers receiving dipyrone at… CONTINUE READING
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