Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic

@article{Hinz2007DipyroneES,
  title={Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic},
  author={B. Hinz and O. Cheremina and Jouri Bachmakov and B. Renner and O. Zolk and M. Fromm and K. Brune},
  journal={The FASEB Journal},
  year={2007},
  volume={21},
  pages={2343 - 2351}
}
Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread prescription or over‐the‐counter use in many countries (e.g., Brazil, Israel, Mexico, Russia, Spain) requires insight into its mode of action. This study therefore addressed the impact of its metabolites 4‐methyl‐amino‐antipyrine (MAA) and 4‐amino‐antipyrine (AA) on peripheral cyclooxygenases (COX). Pharmacokinetics of metabolites and ex vivo COX inhibition were assessed in five volunteers receiving dipyrone at… Expand
Novel bioactive metabolites of dipyrone (metamizol).
Drug Insight: cyclo-oxygenase-2 inhibitors—a critical appraisal
Pharmacological characteristics of metamizole.
Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 71 REFERENCES
Measurement of cyclooxygenase isozyme inhibition in humans: exploring the clinical relevance of biochemical selectivity.
  • C. Patrono
  • Medicine
  • Clinical and experimental rheumatology
  • 2001
Pharmacological analysis of cyclooxygenase-1 in inflammation.
  • C. Smith, Y. Zhang, +7 authors P. Isakson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
COX‐3—a virtual pain target in humans?
  • J. Schwab, T. Beiter, +4 authors H. Schluesener
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2003
Non-acidic pyrazoles: Inhibition of prostaglandin production, carrageenan oedema and yeast fever
Clinical Pharmacokinetics of Dipyrone and its Metabolites
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
...
1
2
3
4
5
...