Dipyridamole suppresses uptake of thymidine in human and bovine cells in vitro

@article{Widstrm1981DipyridamoleSU,
  title={Dipyridamole suppresses uptake of thymidine in human and bovine cells in vitro},
  author={Olle Widstr{\"o}m and Christer Busch and G{\"o}ran Tornling and Bengt S. Nilsson and Gunnar Unge},
  journal={Agents and Actions},
  year={1981},
  volume={11},
  pages={287-289}
}
Dipyridamole has been shown to induce proliferative activity in heart muscle capillary wall cells in the rat. To test whether this effect is due to direct cellular stimulation we tested the substance in various in vitro systems (human lymphocytes, glial cells and endothelial cells; and bovine endothelial cells). During these conditions dipyridamole did not influence cellular proliferation. In all cell systems tested, uptake of labelled thymidine showed an inhibition by dipyridamole. This… CONTINUE READING