Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning.

@article{Miura1992DipyridamolePT,
  title={Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning.},
  author={Tetsuji Miura and Tatsuya Ogawa and Tamio Iwamoto and Kazuaki Shimamoto and Osamu Iimura},
  journal={Circulation},
  year={1992},
  volume={86 3},
  pages={979-85}
}
BACKGROUND Recent studies implicated a key role for adenosine (ADO) receptor activation in the enhancement of ischemic tolerance by ischemic preconditioning. In this study, we aimed to test the hypothesis that dipyridamole, an ADO transport inhibitor, enhances the preconditioning effect. METHODS AND RESULTS Six groups of rabbits underwent 30-minute coronary occlusion and 72-hour reperfusion. Infarct size (IS) and the area-at-risk (AR) were determined by histology and by use of fluorescent… CONTINUE READING
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