Dipyridamole modulates multidrug resistance and intracellular as well as nuclear levels of doxorubicin in B16 melanoma cells.

@article{Damle1994DipyridamoleMM,
  title={Dipyridamole modulates multidrug resistance and intracellular as well as nuclear levels of doxorubicin in B16 melanoma cells.},
  author={Bharat Damle and R. Sathyanarayan Sridhar and Pankaj Desai},
  journal={International journal of cancer},
  year={1994},
  volume={56 1},
  pages={113-8}
}
Simultaneous occurrence of resistance to many chemotherapeutic agents, termed multidrug resistance (MDR), is a complex phenotype. MDR occurs due to several reasons, including over-expression of a 170-kDa membrane-bound protein, called P-glycoprotein (P-gp), which apparently participates in active drug efflux. Multidrug-resistant cells also frequently… CONTINUE READING