Dipsogenic effect of L-5-hydroxytryptophan in rats

  title={Dipsogenic effect of L-5-hydroxytryptophan in rats},
  author={Melvin J. Fregly and Thomas M. Connor and Dianne C. Kikta and Rose M. Threatte},
  journal={Brain Research Bulletin},
The precursor of serotonin, l-hydroxytryptophan (5HTP), is a potent dipsogen in the rat. Peripheral administration of increasing doses of this compound increased water intake in a dose-dependent fashion. Peripheral administration of other analogs of tryptophan, including d-tryptophan, l-tryptophan and acetyltryptophan, failed to affect water intake at a dose at which 5HTP induced maximal drinking (25 mg/kg, SC). The dipsogenic effect of melatonin, one of the metabolites of serotonin, was also… CONTINUE READING


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