Diphtheria: An Emerging Disease

@inproceedings{Ramamurthy2018DiphtheriaAE,
  title={Diphtheria: An Emerging Disease},
  author={Thandavarayan Ramamurthy and Sabahat Azim and Sudeshna Ganguly and Sujit Kumar Bhattacharya},
  year={2018}
}
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheriae which remains as one of the important causes of illness and death among children. Globally, epidemic waves of diphtheria have killed thousands of children in early 1920s, i.e., before the vaccine era. There are four main biotypes of C. diphtheriae available namely C.d. Gravis, C.d. Intermedius, C.d. Mitis, and C.d. Belfanti. Globally, the C.d. Intermedius is most often associated with exotoxin production, although all… Expand
2 Citations
Molecular Docking Simulation based Virtual Screening for The Design of Potential Inhibitors of Heme Oxygenase of Corney Bacterium Diphtheria
Diphtheria is an infectious human disorder affecting upper respiratory tract which is characterized by fever, sore throat, and malaise. It is caused by Corynebacterium diphtheria and other pathogenicExpand
Diphtheria: An Emerging Disease
TLDR
The present review has accumulated all the recent updates on diphtheria and presented a timely discussion on diagnosis and vaccination procedure, which might assist future therapeutics. Expand

References

SHOWING 1-10 OF 30 REFERENCES
Evolution, epidemiology and diversity of Corynebacterium diphtheriae: New perspectives on an old foe.
  • V. Sangal, P. Hoskisson
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2016
TLDR
Molecular epidemiological investigations suggest the existence of outbreak-associated clones with multiple genotypes circulating around the world and a recombination driven diversification of strains within a sequence type and indicate a wider diversity among C. diphtheriae strains than previously appreciated. Expand
Diphtheria outbreak in Maranhão, Brazil: microbiological, clinical and epidemiological aspects
TLDR
Diphtheria remains endemic in Brazil and health professionals need to be aware of the possibility of atypical cases of C. diphtheriae infection, including pharyngitis without pseudomembrane formation. Expand
Corynebacterium diphtheriae: genome diversity, population structure and genotyping perspectives.
  • I. Mokrousov
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2009
TLDR
In this view, CRISPRs and minisatellites are promising genomic markers for development of high-resolution typing schemes and databasing of C. diphtheriae. Expand
Strengthening the laboratory diagnosis of pathogenic Corynebacterium species in the Vaccine era
TLDR
This review provides the overview of the advantages and limitations of different molecular methods and the role of MALDI‐TOF in the laboratory diagnosis of Diphtheria and the contribution of next generation sequencing technology and different genotyping techniques in understanding the pathogenicity, transmission dynamics and epidemiology of the C. diphtheriae. Expand
Molecular and Epidemiological Review of Toxigenic Diphtheria Infections in England between 2007 and 2013
TLDR
The epidemiological and molecular characterization of all toxigenic corynebacterium strains isolated in England between January 2007 and December 2013 demonstrated that the majority (87.5%; 7/8) of C. diphtheriae strains represented new sequence types (STs). Expand
Corynebacterium ulcerans, an emerging human pathogen.
TLDR
This review gives a comprehensive overview of the basic knowledge of C. ulcerans, as well as the recent advances made in the analysis of putative virulence factors. Expand
Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March–June 2015
TLDR
Two novel lineages were identified, namely, toxigenic sequence type (ST) ST-378 and nontoxigenic ST-395, suggesting ongoing circulation of this lineage for >30 years; this ST appears to be endemic only in South Africa. Expand
Diphtheria outbreak in Lao People's Democratic Republic, 2012-2013.
TLDR
Suboptimal DTP3 coverage likely caused the diphtheria outbreak in Lao People's Democratic Republic and three rounds of DTP immunization campaign should be completed, targeting children aged 0-14years in affected provinces. Expand
Diphtheria outbreak with high mortality in northeastern Nigeria
TLDR
Low rates of immunization, delayed clinical recognition of diphtheria and absence of treatment with antitoxin and appropriate antibiotics contributed to this epidemic and its severity. Expand
Diphtheria in the Dominican Republic: reduction of cases following a large outbreak.
TLDR
The 2004-2005 diphtheria outbreak in the Dominican Republic resulted in important and avoidable morbidity and mortality and maintaining high vaccination coverage and diligent surveillance are crucial to preventing diphTheria outbreaks and controlling the disease. Expand
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