Diphenylhydantoin blocks cardiac calcium channels and binds to the dihydropyridine receptor.

  title={Diphenylhydantoin blocks cardiac calcium channels and binds to the dihydropyridine receptor.},
  author={Atsuko Yatani and Susan L. Hamilton and Arthur M. Brown},
  journal={Circulation research},
  volume={59 3},
Diphenylhydantoin was studied for its effects on Ca currents in single isolated guinea pig ventricular cells. The whole-cell patch-clamp technique was used, and Ca currents were studied after suppressing Na and K currents. At low frequencies (0.1 Hz) and negative holding potentials (-50 mV), diphenylhydantoin produced a concentration-dependent decrease in Ca currents without any significant change in the current-voltage relations. Half blocking effect occurred at 2 X 10(-4) M. The effects of… CONTINUE READING

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