Diphenylamine-2-carboxylate, a blocker of the Cl−-conductive pathway in Cl−-transporting epithelia

@article{Stefano2004Diphenylamine2carboxylateAB,
  title={Diphenylamine-2-carboxylate, a blocker of the Cl−-conductive pathway in Cl−-transporting epithelia},
  author={A. Stefano and M. Wittner and E. Schlatter and H. J. Lang and H. C. Englert and R. Greger},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={405},
  pages={S95-S100}
}
  • A. Stefano, M. Wittner, +3 authors R. Greger
  • Published 2004
  • Chemistry, Medicine
  • Pflügers Archiv
  • The present study examines the effects of diphenylamine-2-carboxylate (DPC) in Cl−-transporting epithelia. This substance blocks reversibly the Cl−-conductance present under normal circumstances in the basolateral membrane of the thick ascending limb of the loop of Henle (TAL) and in the apical membrane of shark rectal gland tubules (RGT). This leads to a reduction in active NaCl reabsorption (TAL) and NaCl secretion (RGT) respectively, as measured by the equivalent short circuit current. The… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 27 REFERENCES
    Contraluminal sulfate transport in the proximal tubule of the rat kidney
    • 46
    Properties of the lumen membrane of the cortical thick ascending limb of Henle's loop of rabbit kidney
    • 254
    Mechanism of NaCI secretion in rectal gland tubules of spiny dogfish (Squalus acanthias)
    • Raincr Greger, Eberhard Schlattcr
    • 21