Diphenylamine-2-carboxylate, a blocker of the Cl−-conductive pathway in Cl−-transporting epithelia

  title={Diphenylamine-2-carboxylate, a blocker of the Cl−-conductive pathway in Cl−-transporting epithelia},
  author={Antonio Di Stefano and Monika Wittner and Eberhard Schlatter and Hans Jochen Lang and Heinrich C. Englert and Rainer Greger},
  journal={Pfl{\"u}gers Archiv},
The present study examines the effects of diphenylamine-2-carboxylate (DPC) in Cl−-transporting epithelia. This substance blocks reversibly the Cl−-conductance present under normal circumstances in the basolateral membrane of the thick ascending limb of the loop of Henle (TAL) and in the apical membrane of shark rectal gland tubules (RGT). This leads to a reduction in active NaCl reabsorption (TAL) and NaCl secretion (RGT) respectively, as measured by the equivalent short circuit current. The… CONTINUE READING

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Mechanism of cAMP-stimulation of active NaC1 reabsorption in the isolated perfused medullary thick ascending limb of Henle's loop (mTAL) of mouse nephron

  • E Schlatter, R Greger
  • Pfliigers Arch 400:R22
  • 1984
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