Diphenyl-diselenide suppresses amyloid-β peptide in Caenorhabditis elegans model of Alzheimer's disease.

@article{Zamberlan2014DiphenyldiselenideSA,
  title={Diphenyl-diselenide suppresses amyloid-β peptide in Caenorhabditis elegans model of Alzheimer's disease.},
  author={D C Zamberlan and L P Arantes and M L Machado and Ronaldo Medeiros Golombieski and F{\'e}lix Alexandre Antunes Soares},
  journal={Neuroscience},
  year={2014},
  volume={278},
  pages={40-50}
}
Alzheimer's disease (AD) is the most common and devastating neurodegenerative disease. The etiology of AD has yet to be fully understood, and common treatments remain largely non-efficacious. The amyloid hypothesis posits that extracellular amyloid-β (Aβ) deposits are the fundamental etiological factor of the disease. The present study tested the organoselenium compound diphenyl-diselenide (PhSe)2, which is characterized by its antioxidant and antiinflammatory properties and has shown efficacy… CONTINUE READING
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