Diphenyl diselenide protects against methylmercury-induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen.

@article{Meinerz2017DiphenylDP,
  title={Diphenyl diselenide protects against methylmercury-induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen.},
  author={Daiane Francine Meinerz and Vasco Branco and Michael Aschner and Cristina M. L. Carvalho and Jo{\~a}o Batista T Rocha},
  journal={Journal of applied toxicology : JAT},
  year={2017},
  volume={37 9},
  pages={1073-1081}
}
Exposure to methylmercury (MeHg), an important environmental toxicant, may lead to serious health risks, damaging various organs and predominantly affecting the brain function. The toxicity of MeHg can be related to the inhibition of important selenoenzymes, such as glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). Experimental studies have shown that selenocompounds play an important role as cellular detoxifiers and protective agents against the harmful effects of mercury. The… CONTINUE READING