Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice.

@article{JacquesSilva2001DiphenylDA,
  title={Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice.},
  author={Maria Caroline Jacques-Silva and Cristina Wayne Nogueira and Laurent Broch and {\'E}dina Madeira Flores and Jo{\~a}o Batista T Rocha},
  journal={Pharmacology \& toxicology},
  year={2001},
  volume={88 3},
  pages={
          119-25
        }
}
Sodium selenite (Na2SeO3) is the selenium form used in the composition of dietary supplements, and diphenyl diselenide (PhSe)2 is an important intermediate in organic synthesis, which increases the risk of human exposure to this chemical in the workplace. These compounds have been reported to inhibit the cerebral and hepatic aminolevulinic acid dehydratase (ALA-D) in vitro, and now we show that ascorbic acid can reverse some alterations caused by in vivo selenium exposure, but not ALA-D… Expand
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TLDR
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