Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced neurotoxicity mouse model

@article{Glaser2013DiphenylDA,
  title={Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced neurotoxicity mouse model},
  author={Viviane Glaser and Roberta de Paula Martins and Ana Julia Hoffmann Vieira and Eliana de Medeiros Oliveira and Marcos Raniel Straliotto and Jorge Humberto Mukdsi and Alicia In{\'e}s Torres and Andreza Fabro de Bem and Marcelo Farina and Jo{\~a}o Batista Teixeira da Rocha and Ana Luc{\'i}a De Paul and Alexandra Latini},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={390},
  pages={1-8}
}
Interest in biochemistry of organoselenium compound has increased in the last decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of diphenyl diselenide (PhSe)2 (5 μmol/kg), in a mouse model of methylmercury (MeHg)-induced brain toxicity. Swiss male mice were divided into four experimental groups: control, (PhSe)2 (5 μmol/kg, subcutaneous administration), MeHg (40 mg/L, in tap water), and MeHg + (PhSe)2. After the treatment (21 days), the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer’s type model in rats

  • S Pinton, CA Bruning, CE Sartori Oliveira, M Prigol, CW Nogueira
  • J Nutr Biochem
  • 2013

Diphenyl diselenidemodulation of macrophage activation: down-regulation of classical and alternative activation markers

  • LL Rupil, AF de Bem, GA Roth
  • Innate Immun 18:627–637
  • 2012
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