Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review.

@article{Banerji2007DiphenhydramineVN,
  title={Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review.},
  author={Aleena Banerji and Aidan A. Long and Carlos A. Camargo},
  journal={Allergy and asthma proceedings},
  year={2007},
  volume={28 4},
  pages={
          418-26
        }
}
First-generation antihistamines can have adverse effects on the central nervous system and thereby complicate discharge planning from the emergency department (ED). Newer antihistamines are potentially safer, causing less sedation with similar efficacy. The aim of this study was to review the literature to better define which antihistamines are good options for the treatment of acute allergic reactions. A Medline search was conducted to identify English language articles published between… 

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