Diphenhydramine potentiates narcotic but not endogenous opioid analgesia

  title={Diphenhydramine potentiates narcotic but not endogenous opioid analgesia},
  author={K. Carr and J. Hiller and E. J. Simon},
The analgesic effect of morphine in rats, as reflected in elevated thresholds for tail shock induced vocalizations, was markedly potentiated by the antihistamine, diphenhydramine. Intrinsic to the behavioral test paradigm employed are stressors which mobilize endogenous opioid activity as verified by the hyperalgesic effect of naloxone. Diphenhydramine failed to potentiate the analgesic effect of such endogenous opioid activity. The potentiating effect of antihistamines may therefore be… Expand
Analgesic effect of clobazam in chronic low‐back pain but not in experimentally induced pain
The aim of this study is to explore the effect of GABA modulation on chronic low‐back pain and on quantitative sensory tests. Expand
Antihistamines as analgesics
  • R. Raffa
  • Medicine
  • Journal of clinical pharmacy and therapeutics
  • 2001
Histamine activates pain‐transmitting nerve fibres, releases pain‐related neuropeptides, and is painful when injected into the skin, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus. Expand
Medial thalamic injection of opioid agonists: μ-agonist increases while κ-agonist decreases stimulus thresholds for pain and reward
Selective agonists for mu- and kappa-opioid receptor types were infused, bilaterally, into the intralaminar central lateral nucleus of the rat. Subcataleptic doses of the mu-agonist, DAGO (0.25 andExpand
Open channel block of NMDA receptors by diphenhydramine
Evidence is provided that the NMDA receptor antagonism of diphenhydramine contribute to its sedative and potentially LTP-related effects like analgesia and amnesia. Expand
Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect
A case of serotonin syndrome is demonstrated following the administration of diphenhydramine for seasonal allergies in a patient on tramadol for neck pain. Expand
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
It is suggested that ReN 1869, via H(1) blockade, counteracts the effect of histamine liberated from activated mast cells and inhibits pain transmission in the dorsal spinal cord. Expand
Diphenhydramine Definitely Suppresses Fentanyl-Induced Cough During General Anesthesia Induction: A Double-Blind, Randomized, and Placebo-Controlled Study
It is determined that diphenhydramine (30 mg, IV) bolus injection 2 min before fentanyl injection can prevent FIC and PONV and also reduce analgesic requirement inthe recovery room. Expand
Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States
It is suggested that histamine released from brain mast cells is wake-promoting, and emphasizes the physiological and pharmacological importance of brainmast cells in the regulation of sleep and fundamental neurobehavior. Expand
Simultaneous assay of codeine phosphate and diphenhydramine hydrochloride in cough mixtures by zero-order derivative UV spectrophotometry
This study evaluated a zero-order derivative UV spectrophotometric method for the simultaneous determination of binary components, codeine phosphate and diphenyhydramine HCl in cough mixtures. TheExpand
Pulmonary intravascular talcosis mimicking miliary tuberculosis in an intravenous drug addict
The importance of considering rare causes of pulmonary disseminations with attempts to identify the causative agent is referred to and the use of antituberculosis treatment without confirmation of microbiological diagnosis of tuberculosis is warned against. Expand


Potentiation of opioid analgesia by H1 and H2 antagonists.
Several H1 antagonists and the H2 antagonist cimetidine markedly potentiated analgesia of opioids (morphine, fentanyl and nalbuphine) and no motor impairment occurred with any of the drugs and drug combinations at the doses studied. Expand
Endogenous opioid ligands may mediate stress-induced changes in the affective properties of pain related behavior in rats.
The data suggest that immobilization-induced changes in pain related behavior may be mediated by an opiate receptor ligand system and that this endogenous system may be mediating the affective but not the sensory properties ofPain related behavior. Expand
Analgesic potentiation and the distribution of morphine in the presence of triplennamine in mice.
Naloxone completely reversed the analgesia of MS and the MS-TRP combination and the distribution of 3H morphine in representative brain areas and plasma was not different in the presence or absence of triplennamine. Expand
The effect of tripelennamine alone and in combination with opiates to produce antinociception in mice.
The partial abolition of Tp ANTI, in contrast to complete blockade of M effects with Nx, appears to indicate that Tp can stimulate the opiate receptor as well as another receptor for ANTI at a different locus. Expand
Effects of the combination of tripelennamine and Pentazocine at the behavioral and molecular levels
  • H. Shannon, T. Su
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
  • 1982
Results are consistent with the hypothesis that the potentiation of the morphine-like effects of pentazocine by tripelennamine which was observed behaviorally was not due to molecular interactions at the morphine receptor. Expand