Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo.

@article{Or2016DiphenhydramineIM,
  title={Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo.},
  author={Chi-Hung R Or and Hong-Lin Su and Wee-Chyan Lee and Shu-Yi Yang and Cheesang Ho and Chia-Che Chang},
  journal={Oncology reports},
  year={2016},
  volume={36 6},
  pages={
          3465-3471
        }
}
  • Chi-Hung R Or, Hong-Lin Su, +3 authors Chia-Che Chang
  • Published 2016
  • Medicine, Biology
  • Oncology reports
  • Melanoma is the most aggressive skin malignancy with a high rate of mortality and is frequently refractory to many therapeutics, thus demanding the discovery of novel effective anti-melanoma agents. Diphenhydramine (DPH) is an H1 histamine receptor antagonist and a relatively safe drug. Previous studies have revealed the in vitro cytotoxicity of DPH against melanoma cells, but the mechanisms involved concerning its cytotoxicity and the in vivo anti-melanoma effect remain unknown. We herein… CONTINUE READING

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