Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo.

@article{Or2016DiphenhydramineIM,
  title={Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo.},
  author={Chi-Hung R. Or and H M Su and Wee-Chyan Lee and Shu-Yi Yang and Cheesang Ho and C Chang},
  journal={Oncology reports},
  year={2016},
  volume={36 6},
  pages={3465-3471}
}
Melanoma is the most aggressive skin malignancy with a high rate of mortality and is frequently refractory to many therapeutics, thus demanding the discovery of novel effective anti-melanoma agents. Diphenhydramine (DPH) is an H1 histamine receptor antagonist and a relatively safe drug. Previous studies have revealed the in vitro cytotoxicity of DPH against… CONTINUE READING