Diphenhydramine: Pharmacokinetics and Pharmacodynamics in Elderly Adults, Young Adults, and Children

@article{Simons1990DiphenhydraminePA,
  title={Diphenhydramine: Pharmacokinetics and Pharmacodynamics in Elderly Adults, Young Adults, and Children},
  author={K. Simons and W. Watson and T. J. Martin and Ms. Xue Yu Chen and F. Simons},
  journal={The Journal of Clinical Pharmacology},
  year={1990},
  volume={30}
}
The pharmacokinetics and pharmacodynamics of the H1‐receptor antagonist diphenhydramine were studied in 21 fasting subjects divided into three age groups: elderly, (mean age 69.4 ± 4.3 years), young adults, (mean age 31.5 ± 10.4 years), and children, (mean age 8.9 ± 1.7 years). All subjects ingested a single dose of diphenhydramine syrup 1.25 mg/kg, in mean doses of 86.0 ± 7.3 mg, 87.9 ± 12.4 mg, and 39.5 ± 8.4 mg, respectively. Blood samples were collected hourly for 6 hours, every 2 hours… Expand
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TLDR
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Maximum plasma levels of diphenhydramine in normal subjects ranged from 81 to 159 ng/ml in 2 to 4 hr after single 100 mg oral doses, with an estimated half‐life of 7 hr. Multiple oral doses of 50 mgExpand
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