Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Abstract

Recent studies into the physiology of the incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have added stimulation of beta-cell growth, differentiation, and cell survival to well-documented, potent insulinotropic effects. Unfortunately, the therapeutic potential of these hormones is limited by their rapid… (More)

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@article{Pospisilik2003DipeptidylPI, title={Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.}, author={John Andrew Pospisilik and Jennifer H Martin and Timothy J Doty and Jan A. Ehses and Nathalie Pamir and Francis C Lynn and Shalea Piteau and H Demuth and Christopher S. Mcintosh and Raymond A. Pederson}, journal={Diabetes}, year={2003}, volume={52 3}, pages={741-50} }