Dipeptidyl peptidase IV (DPPIV), a candidate tumor suppressor gene in melanomas is silenced by promoter methylation.

@article{McGuinness2008DipeptidylPI,
  title={Dipeptidyl peptidase IV (DPPIV), a candidate tumor suppressor gene in melanomas is silenced by promoter methylation.},
  author={Carolyn McGuinness and Umadevi V. Wesley},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={2435-43}
}
Dipeptidyl peptidase IV (DPPIV), a serine protease is expressed by normal melanocytes but not by melanomas, the malignant counterpart. DPPIV is encoded by a gene that contains a 5 CpG island spanning a transcriptional regulatory region. Previously we have demonstrated that DPPIV abrogates growth factor independence and functions as a tumor suppressor gene in melanomas. In this study we show that loss of DPPIV occurs at RNA level and demethylating agent, 5-aza-2'-deoxycytidine (5-AZA-Cdr… CONTINUE READING

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Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
melanocyteIs normal cell origin of diseasemelanoma
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Previously we have demonstrated that DPPIV abrogates growth factor independence and functions as a tumor suppressor gene in melanomas .
Previously we have demonstrated that DPPIV abrogates growth factor independence and functions as a tumor suppressor gene in melanomas .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
Dipeptidyl peptidase IV ( DPPIV ) , a serine protease is expressed by normal melanocytes but not by melanomas , the malignant counterpart .
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