Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell-derived factor-1α.

@article{Connelly2016DipeptidylPI,
  title={Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell-derived factor-1α.},
  author={Kim A Connelly and Andrew Advani and Yanling Zhang and Suzanne L. Advani and Golam Kabir and Armin Abadeh and Jean-François Desjardins and Melissa C Mitchell and Kerri Thai and Richard E Gilbert},
  journal={Journal of diabetes},
  year={2016},
  volume={8 1},
  pages={
          63-75
        }
}
BACKGROUND In addition to degrading glucagon-like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DPP-4) inactivates several chemokines, including stromal cell-derived factor-1α (SDF-1α), a pro-angiogenic and cardiomyocyte protective protein. We hypothesized that DPP-4 inhibition may confer benefit following myocardial infarction (MI) in the diabetic setting as a consequence of enhanced SDF-1α availability rather than potentiating GLP-1. To test this we compared the effects of saxagliptin with those… CONTINUE READING
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