Dipeptidyl Peptidase-4 Inhibitors, Peripheral Arterial Disease, and Lower Extremity Amputation Risk in Diabetic Patients.

@article{Chang2017DipeptidylPI,
  title={Dipeptidyl Peptidase-4 Inhibitors, Peripheral Arterial Disease, and Lower Extremity Amputation Risk in Diabetic Patients.},
  author={Chun-Chin Chang and Yung-Tai Chen and Chien-Yi Hsu and Yu-wen Su and Chun-Chih Chiu and H. -S. Leu and P N Huang and Jaw-Wen Chen and S. -R. Lin},
  journal={The American journal of medicine},
  year={2017},
  volume={130 3},
  pages={348-355}
}
BACKGROUND Recent studies have elucidated the vascular protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitors. However, to date, no large-scale studies have been carried out to determine the impact of DPP-4 inhibitors on the occurrence of peripheral arterial disease, and lower extremity amputation risk in patients with type 2 diabetes mellitus. METHODS We conducted a retrospective registry analysis using Taiwan's National Health Insurance Research Database to investigate the… CONTINUE READING
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