Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

@inproceedings{Marfella2012DipeptidylP4,
  title={Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes},
  author={Raffaele Marfella and Ferdinando Carlo Sasso and Maria Rosaria Rizzo and Pasquale Paolisso and Michelangela Barbieri and Vincenzo Padovano and Ornella Carbonara and Pasquale Gualdiero and Pasquale Petronella and Francesca Ferraraccio and Antonello Petrella and Raffaele Canonico and Ferdinando Campitiello and Angela Della Corte and Giuseppe Paolisso and Silvestro Canonico},
  booktitle={Experimental diabetes research},
  year={2012}
}
The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia. With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last months, in certain cases years; 19-35% of ulcers are reported as nonhealing. As no efficient therapy is available, it… CONTINUE READING

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