Dipeptide synthesis by L-amino acid ligase from Ralstonia solanacearum.

  title={Dipeptide synthesis by L-amino acid ligase from Ralstonia solanacearum.},
  author={Kuniki Kino and Yuji Nakazawa and Makoto Yagasaki},
  journal={Biochemical and biophysical research communications},
  volume={371 3},
Despite its utility, dipeptides have not been widely used due to the absence of an efficient manufacturing method. Recently, a novel method for effective production of dipeptides using l-amino acid alpha-ligase (Lal) is presented. Lal, which is only identified in Bacillus subtilis, catalyzes dipeptide synthesis from unprotected amino acids in an ATP-dependent manner. However, not all the dipeptide can be synthesized by Lal from B. subtilis (BsLal) due to its substrate specificity. Here, we… CONTINUE READING

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