Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

@article{Nielsen2001DipeptideMP,
  title={Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.},
  author={Carsten Uhd Nielsen and Rikke Andersen and Birger Brodin and Sven Frokjaer and Mitchell E. Taub and Bente Steffansen},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={76 1-2},
  pages={129-38}
}
The human intestinal di/tri-peptide carrier, hPepT1, has been suggested as a drug delivery target via increasing the intestinal transport of low permeability compounds by designing peptidomimetic prodrugs. Model ester prodrugs using the stabilized dipeptides D-Glu-Ala and D-Asp-Ala as pro-moieties for benzyl alcohol have been shown to maintain affinity for hPepT1. The primary aim of the present study was to investigate if modifications of the benzyl alcohol model drug influence the… CONTINUE READING

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