Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility.


Dioxychlorane is a five-membered cyclic halogenated diether which has been reported to be anesthetic at an inspired concentration of 0.3% atm and to have an oil/gas partition coefficient to 260 to 275. These values suggested that dioxychlorane might represent a significant deviation from the correlation of anesthetic potency with lipid solubility. However… (More)


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