Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance

  title={Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance},
  author={J. Lind{\'e}n and S. Lensu and J. Tuomisto and R. Pohjanvirta},
  journal={Frontiers in Neuroendocrinology},
  • J. Lindén, S. Lensu, +1 author R. Pohjanvirta
  • Published 2010
  • Chemistry, Medicine
  • Frontiers in Neuroendocrinology
  • Dioxins are ubiquitous environmental contaminants that have attracted toxicological interest not only for the potential risk they pose to human health but also because of their unique mechanism of action. This mechanism involves a specific, phylogenetically old intracellular receptor (the aryl hydrocarbon receptor, AHR) which has recently proven to have an integral regulatory role in a number of physiological processes, but whose endogenous ligand is still elusive. A major acute impact of… CONTINUE READING
    93 Citations

    Figures, Tables, and Topics from this paper

    Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor.
    • 495
    • Highly Influenced
    • PDF
    Dioxins: diagnostic and prognostic challenges arising from complex mechanisms
    • 9
    Mechanisms of xenobiotic receptor activation: Direct vs. indirect.
    • 49
    Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity
    • 7
    • PDF
    TCDD dysregulation of 13 AHR-target genes in rat liver.
    • 31
    Is the fear of dioxin cancer more harmful than dioxin?
    • 19
    Defining Molecular Sensors to Assess Long-Term Effects of Pesticides on Carcinogenesis
    • 9
    • PDF
    Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration
    • 9
    • PDF


    Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor.
    • 122
    Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
    • P. Mandal
    • Chemistry, Medicine
    • Journal of Comparative Physiology B
    • 2005
    • 504
    Dioxin Toxicology and the Aryl Hydrocarbon Receptor: Insights from Fish and Other Non-traditional Models
    • M. Hahn
    • Biology, Medicine
    • Marine Biotechnology
    • 2001
    • 91
    Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction
    • 219
    • PDF
    The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles.
    • 61
    Aryl hydrocarbon receptors: diversity and evolution.
    • M. Hahn
    • Biology, Chemistry
    • Chemico-biological interactions
    • 2002
    • 573
    The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
    • 295
    The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways.
    • 339