Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects.

@article{Fracchiolla2011DioxinEO,
  title={Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects.},
  author={Nicola Stefano Fracchiolla and Katia Todoerti and Pier Alberto Bertazzi and Federica Servida and P. Poggi – Corradini and Cristiana Carniti and Antonio Colombi and Angela Cecilia Pesatori and Antonino Neri and Giorgio Lambertenghi Deliliers},
  journal={Toxicology},
  year={2011},
  volume={283 1},
  pages={18-23}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has a large number of biological effects, including skin, cardiovascular, neurologic diseases, diabetes, infertility, cancers and immunotoxicity. We analysed the in vitro TCDD effects on human CD34+ cells and tested the gene expression modulation by means of microarray analyses before and after TCDD exposure. We… CONTINUE READING