Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate.

@article{Vezina2008DioxinCV,
  title={Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate.},
  author={Chad M Vezina and Sarah Hicks Allgeier and Robert W. Moore and T M Lin and Jeffrey C Bemis and Heather A Hardin and Thomas A Gasiewicz and Richard Einer Peterson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 2},
  pages={488-96}
}
Prostate ductal development is initiated by androgen-dependent signals in fetal urogenital sinus (UGS) mesenchyme that stimulate prostatic bud formation in UGS epithelium. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, 5 microg/kg maternal dose) inhibited ventral and dorsolateral but not anterior prostatic budding. We sought to determine which stage of budding, specification or initiation, was inhibited. Ventral prostatic bud formation was maximally inhibited when TCDD exposure spanned E15.5-16.5… CONTINUE READING

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