Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

@article{Mandal2005DioxinAR,
  title={Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology},
  author={Prabir Kumar Mandal},
  journal={Journal of Comparative Physiology B},
  year={2005},
  volume={175},
  pages={221-230}
}
  • P. Mandal
  • Published 8 April 2005
  • Biology, Chemistry
  • Journal of Comparative Physiology B
A highly persistent trace environmental contaminant and one of the most potent toxicants known is dioxin (2,3,7,8-tetrachlorodibenzo-para-dioxin or TCDD). TCDD induces a broad spectrum of biological responses, including induction of cytochrome P-450 1A1 (CYP1A1), disruption of normal hormone signaling pathways, reproductive and developmental defects, immunotoxicity, liver damage, wasting syndrome, and cancer. Its classification was upgraded from “possible human carcinogen” (group 2B) to “human… 

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TLDR
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Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.

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